What is the primary reason for the rapid termination of action of a single intravenous bolus of Fentanyl?
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Correct answer: Redistribution from the brain to skeletal muscle and fat
Fentanyl is highly lipophilic and enters the brain quickly. However, its effect wears off rapidly after a single dose because it redistributes down its concentration gradient into less perfused peripheral tissues, even before significant metabolism occurs.
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