Loperamide is used as an antidiarrheal medication because it:
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Correct answer: Is a Mu-agonist that P-glycoprotein pumps back out of the CNS
Loperamide is a potent Mu-agonist in the GI tract. While it can cross the blood-brain barrier, it is immediately pumped back out by the efflux transporter P-glycoprotein, preventing CNS effects at therapeutic doses.
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