Which opioid analgesic also acts as an inhibitor of both norepinephrine and serotonin reuptake?
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Correct answer: Tramadol
Tramadol has a dual mechanism: it is a weak Mu-agonist and a reuptake inhibitor of norepinephrine and serotonin. This makes it particularly effective for neuropathic pain but increases the risk of seizures and serotonin syndrome.
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