Which of the following is the primary proposed mechanism of action for Lithium in the treatment of Bipolar Disorder?
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Correct answer: Inhibition of inositol monophosphatase
Lithium inhibits the inositol signaling pathway by depleting free inositol through the inhibition of inositol monophosphatase. This 'inositol depletion hypothesis' suggests that overactive signaling in manic states is dampened by reducing the recycling of phosphoinositides.
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