A patient on long-term Lithium therapy develops polyuria and polydipsia. This is most likely due to which of the following?
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Correct answer: Nephrogenic Diabetes Insipidus
Lithium can antagonize the effects of Antidiuretic Hormone (ADH) in the collecting duct by inhibiting adenylate cyclase. This results in the inability to concentrate urine, leading to Nephrogenic Diabetes Insipidus.
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