Which mood stabilizer is associated with a rare but life-threatening dermatological reaction known as Stevens-Johnson Syndrome (SJS), requiring a very slow dose titration?
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Correct answer: Lamotrigine
Lamotrigine carries a black box warning for serious rashes, including SJS and Toxic Epidermal Necrolysis. To minimize this risk, the drug must be started at a low dose and escalated gradually over several weeks.
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