Which of the following electrolyte disturbances is most likely to increase the risk of Lithium toxicity by increasing its renal reabsorption?
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Correct answer: Hyponatremia
Lithium is handled by the kidneys similarly to sodium. In states of hyponatremia (due to diuretics, sweating, or low intake), the proximal tubule increases the reabsorption of both sodium and lithium, leading to toxic lithium accumulation.
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