Which antiepileptic drug is an irreversible inhibitor of GABA transaminase (GABA-T) and carries a risk of permanent visual field loss?
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Correct answer: Vigabatrin
Vigabatrin increases synaptic GABA levels by permanently inactivating the enzyme responsible for its breakdown. Its use is limited to refractory cases due to the significant risk of irreversible peripheral visual field constriction (retinal toxicity).
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