Lamotrigine is often preferred for women of childbearing age due to its lower teratogenic risk. However, its metabolism is significantly increased by which of the following?
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Correct answer: Oral contraceptives
Estrogen induces the glucuronidation enzymes (UGT1A4) that metabolize Lamotrigine. Women starting or stopping oral contraceptives often require significant dose adjustments of Lamotrigine to maintain therapeutic levels.
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