A patient taking Carbamazepine develops severe hyponatremia. This is primarily due to which of the following?
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Correct answer: Syndrome of inappropriate antidiuretic hormone secretion
Carbamazepine can increase the sensitivity of the renal collecting ducts to ADH or stimulate its release. This leads to water retention and dilutional hyponatremia, which requires monitoring of serum electrolytes in treated patients.
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