Which antiepileptic agent is a water-soluble prodrug that can be given by intramuscular injection, avoiding the local tissue necrosis seen with the intravenous parent drug?
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Correct answer: Fosphenytoin
Fosphenytoin is a water-soluble phosphate ester of Phenytoin. It avoids the high pH and propylene glycol solvent required for IV Phenytoin, reducing the risk of local tissue necrosis and allowing for IM administration.
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