Antiepileptics · Pharmacology

What is the primary reason that Carbamazepine should be avoided in patients with absence seizures?

  1. It causes severe gastric upset in these patients
  2. It can actually exacerbate absence seizures
  3. It is too toxic for children
  4. It only works on GABA receptors
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Correct answer: It can actually exacerbate absence seizures

Sodium channel blockers like Carbamazepine and Phenytoin can worsen absence and myoclonic seizures. Proper diagnosis of the seizure type is essential before selecting an antiepileptic to avoid paradoxical seizure exacerbation.

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