Gabapentin and Pregabalin do not act directly on GABA receptors. Instead, they bind to which target?
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Correct answer: The alpha-2-delta subunit of voltage-gated calcium channels
Despite their structural similarity to GABA, these drugs bind to the alpha-2-delta subunit of P/Q-type calcium channels. This binding reduces the presynaptic release of excitatory neurotransmitters like glutamate.
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