Why are TCAs generally avoided in patients with benign prostatic hyperplasia (BPH) or narrow-angle glaucoma?
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Correct answer: They potently block muscarinic receptors
TCAs block muscarinic receptors, leading to 'atropine-like' side effects. This can cause urinary retention in men with BPH and can trigger an acute attack of narrow-angle glaucoma due to pupillary dilation.
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