Which of the following antidepressants is often used at low doses as a sleep aid due to its potent H1-histamine receptor antagonism?
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Correct answer: Trazodone
Trazodone is highly sedating because it is a potent blocker of H1 receptors and alpha-1 receptors. For this reason, it is more commonly used to treat insomnia in depressed patients than as a primary antidepressant.
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