Serotonin Syndrome is a life-threatening condition that can occur when SSRIs are combined with which of the following substances?
Show answer and explanation
Correct answer: St. John's Wort
St. John's Wort has weak MAOI and reuptake inhibition properties. When taken with SSRIs, it can lead to excessive serotonergic activity, resulting in mental status changes, autonomic instability, and neuromuscular abnormalities.
Keep practicing
More Antidepressants questions
- Which antidepressant acts as an antagonist at presynaptic alpha-2 autoreceptors, leading to increased release of both serotonin and norepin…
- Which SSRI has a half-life of about 4–6 days and an active metabolite that persists in the body for weeks?
- Which of the following is a potential side effect of Trazodone that requires immediate medical attention?
- Why are TCAs generally avoided in patients with benign prostatic hyperplasia (BPH) or narrow-angle glaucoma?
- Vortioxetine is classified as a 'serotonin modulator and stimulator' because it inhibits SERT and also acts as a:
- Which of the following antidepressants is often used at low doses as a sleep aid due to its potent H1-histamine receptor antagonism?