Which SSRI has a half-life of about 4–6 days and an active metabolite that persists in the body for weeks?
Show answer and explanation
Correct answer: Fluoxetine
Fluoxetine has the longest half-life of all SSRIs. Its active metabolite, norfluoxetine, has an even longer half-life (7–15 days), which makes it a good option for patients who occasionally forget a dose, but requires a longer 'washout' period.
Keep practicing
More Antidepressants questions
- Which of the following is a potential side effect of Trazodone that requires immediate medical attention?
- Why are TCAs generally avoided in patients with benign prostatic hyperplasia (BPH) or narrow-angle glaucoma?
- Vortioxetine is classified as a 'serotonin modulator and stimulator' because it inhibits SERT and also acts as a:
- Which of the following antidepressants is often used at low doses as a sleep aid due to its potent H1-histamine receptor antagonism?
- Which lab parameter should be monitored in elderly patients starting an SSRI, due to the risk of SIADH?
- What is the clinical significance of the 'black box warning' on all antidepressant medications?