Anticoagulants · Pharmacology

What is the primary route of elimination for Dabigatran etexilate?

  1. Hepatic metabolism via CYP3A4
  2. Renal excretion unchanged
  3. Biliary excretion
  4. Degradation by plasma esterases
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Correct answer: Renal excretion unchanged

Approximately 80% of dabigatran is excreted unchanged by the kidneys. This makes it crucial to adjust doses or avoid the drug entirely in patients with significant renal impairment.

Difficulty: Medium Question 12 of 20

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