A patient on Warfarin consumes a large amount of leafy green vegetables (rich in Vitamin K). What is the likely effect on their INR?
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Correct answer: The INR will decrease, increasing clotting risk
Vitamin K directly antagonizes the effect of Warfarin. Increasing dietary Vitamin K provides the liver with more substrate to produce clotting factors, thereby reducing the anticoagulant effect and lowering the INR.
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