Anticoagulants · Pharmacology

Protamine sulfate is used to neutralize the effects of Heparin. Which property of Protamine allows this interaction?

  1. It is a highly acidic molecule that degrades Heparin
  2. It is a basic protein that forms a salt with Heparin
  3. It competes for the binding site on Antithrombin III
  4. It stimulates the liver to produce more clotting factors
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Correct answer: It is a basic protein that forms a salt with Heparin

Protamine is positively charged (basic) and Heparin is negatively charged (acidic). They combine through electrostatic interaction to form a stable, inactive salt, effectively neutralizing Heparin's anticoagulant activity.

Difficulty: Medium Question 9 of 20

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