Tetracyclines · Pharmacology

What is the primary route of elimination for Tetracycline (the parent drug of the class)?

  1. Renal glomerular filtration
  2. Biliary secretion
  3. Sweat and lacrimal fluid
  4. Hepatic metabolism via CYP450
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Correct answer: Renal glomerular filtration

Short-acting tetracyclines like Tetracycline and Oxytetracycline are primarily eliminated unchanged in the urine. Dose reduction is mandatory for these specific agents in patients with kidney disease.

Difficulty: Medium Question 13 of 20

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