In the treatment of periodontitis, sub-antimicrobial doses of Doxycycline are used to inhibit which host enzyme?
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Correct answer: Matrix metalloproteinases
Tetracyclines have non-antibiotic properties, including inhibition of matrix metalloproteinases such as collagenase. Blocking these enzymes prevents breakdown of periodontal connective tissue and bone.
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More Tetracyclines questions
- Which of the following is a common supra-infection associated with the use of broad-spectrum tetracyclines?
- Minocycline is often used in the treatment of which chronic dermatological condition?
- Which of the following is true regarding the volume of distribution (Vd) of tetracyclines?
- How should a patient be instructed to take Doxycycline to maximize absorption while minimizing GI upset?
- What is the primary mechanism of action of tetracyclines in inhibiting bacterial growth?
- Which of the following is the most common mechanism of bacterial resistance to tetracyclines?