Which sulfonamide is a prodrug used in the treatment of inflammatory bowel disease (IBD) like Ulcerative Colitis?
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Correct answer: Sulfasalazine
Sulfasalazine is poorly absorbed in the small intestine. In the colon, bacterial enzymes break the azo bond to release sulfapyridine and 5-aminosalicylic acid (mesalamine), the latter of which provides the local anti-inflammatory effect.
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More Sulfonamides questions
- Sulfadoxine combined with Pyrimethamine is primarily used in the treatment of which infection?
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