Which of the following is the most common use for oral Sulfamethoxazole-Trimethoprim (TMP-SMX)?
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Correct answer: Uncomplicated urinary tract infection
TMP-SMX is a first-line agent for uncomplicated urinary tract infections because it is active against common Gram-negative uropathogens such as E. coli and concentrates in the urine. Rising resistance has limited its empirical use in some regions.
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