Sulfonamides may increase the effects of which of the following drugs by displacing them from plasma albumin or inhibiting their metabolism?
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Correct answer: Warfarin
Sulfonamides are highly bound to plasma albumin and can displace warfarin and the sulfonylureas from binding sites, and they also inhibit their hepatic metabolism. The result is an increased risk of bleeding with warfarin and of hypoglycaemia with sulfonylureas.
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