Sulfonamides are primarily metabolized in the liver by which process?
Show answer and explanation
Correct answer: N-acetylation
The major metabolic pathway for sulfonamides is N-acetylation. The acetylated metabolites have no antimicrobial activity but retain the potential for toxicity, particularly crystalluria.
Keep practicing
More Sulfonamides questions
- What is the drug of choice for the prevention and treatment of Pneumocystis jirovecii pneumonia (PCP) in immunocompromised patients?
- Which structural feature is essential for the antimicrobial activity of a sulfonamide molecule?
- A patient taking Sulfamethoxazole-Trimethoprim develops a significant rise in serum potassium. This is most likely due to the effect of whi…
- Sulfadiazine combined with Pyrimethamine is the first-line regimen for the treatment of which condition?
- Which of the following describes the primary mechanism of action of sulfonamides?
- Why are sulfonamides bacteriostatic against many bacteria but relatively non-toxic to mammalian cells?