Which of the following is a severe, potentially fatal hypersensitivity reaction associated with sulfonamides involving skin and mucous membranes?
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Correct answer: Stevens-Johnson syndrome
Stevens-Johnson syndrome and its more severe form, toxic epidermal necrolysis, are rare but characteristic hypersensitivity reactions to sulfonamides. Both involve widespread blistering and epidermal sloughing of skin and mucous membranes, and require immediate withdrawal of the drug.
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