Sulfonamides can cause the formation of crystals in the urine (crystalluria). Which patient instruction is essential to minimize this risk?
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Correct answer: Maintain a high fluid intake to ensure adequate urine volume
Sulfonamides and their acetylated metabolites are less soluble in acidic or concentrated urine. Maintaining high fluid intake helps dilute the urine and prevents the precipitation of crystals in the renal tubules.
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