Fluoroquinolones · Pharmacology

Which of the following describes the 'post-antibiotic effect' (PAE) of fluoroquinolones?

Bacterial growth resumes immediately after the antibiotic is cleared from the site
The drug becomes progressively more toxic after hepatic metabolism
Bacteria become more sensitive to heat following drug exposure
Growth remains suppressed after the concentration falls below the MIC

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Correct answer: Growth remains suppressed after the concentration falls below the MIC

Fluoroquinolones exhibit a significant PAE against many pathogens. This allows for less frequent dosing intervals while still maintaining antimicrobial efficacy.

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