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Fluoroquinolones · Pharmacology

The development of resistance to fluoroquinolones is most commonly due to:

  1. Enzymatic inactivation of the antibiotic by bacterial acetyltransferase enzymes
  2. Bypass of the folate synthesis pathway using preformed folic acid
  3. Degradation of the drug by bacterial beta-lactamase enzymes
  4. Chromosomal mutations in the quinolone resistance-determining region
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Correct answer: Chromosomal mutations in the quinolone resistance-determining region

Resistance most often arises from point mutations in the quinolone resistance-determining region of the genes encoding DNA gyrase and Topoisomerase IV. These mutations lower the binding affinity of the drug for its target enzymes.

Difficulty: Medium Question 15 of 20

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