Which enzyme is the primary target of fluoroquinolones in Gram-positive organisms such as Streptococcus pneumoniae?
Show answer and explanation
Correct answer: Topoisomerase IV
In many Gram-positive bacteria, Topoisomerase IV is the principal target. Inhibition of this enzyme interferes with the separation of replicated chromosomal DNA into daughter cells during cell division.
Keep practicing
More Fluoroquinolones questions
- Fluoroquinolones carry a Boxed Warning from the FDA regarding the increased risk of which musculoskeletal complication?
- Which of the following fluoroquinolones is known as a 'respiratory fluoroquinolone' due to its enhanced activity against S. pneumoniae?
- Which pharmacokinetic interaction significantly reduces the oral bioavailability of fluoroquinolones?
- A patient taking a fluoroquinolone for a complicated UTI is advised to avoid intense sunlight. This is to prevent which adverse effect?
- Which fluoroquinolone is unique because it does not require dose adjustment in renal failure due to its primary elimination via the liver?
- Fluoroquinolones should be used with caution in patients with a history of which cardiac conduction abnormality?