Which historical 'first-generation' quinolone was used primarily for uncomplicated UTIs but lacked systemic activity?
Show answer and explanation
Correct answer: Nalidixic acid
Nalidixic acid is the prototype quinolone. It reaches therapeutic concentrations only in the urine and lacks the fluorine substituent that gives modern fluoroquinolones their broad systemic distribution.
Keep practicing
More Fluoroquinolones questions
- Fluoroquinolones are generally avoided in pediatric patients and during pregnancy because of observed toxicity to which tissue in animal st…
- Which fluoroquinolone has the most potent activity against Pseudomonas aeruginosa?
- A patient on a fluoroquinolone develops sudden onset of severe abdominal or back pain. The clinician must immediately rule out which rare b…
- The development of resistance to fluoroquinolones is most commonly due to:
- Which of the following describes the 'post-antibiotic effect' (PAE) of fluoroquinolones?
- Fluoroquinolones can cause significant dysglycemia (both hypo- and hyperglycemia), especially in diabetic patients. Which agent was withdra…