Which carbapenem is unique because it lacks activity against Pseudomonas aeruginosa and Acinetobacter species?
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Correct answer: Ertapenem
Ertapenem has a long half-life allowing for once-daily dosing but has a limited spectrum compared to other carbapenems. It is often referred to as 'the monkey-wrench carbapenem' because it lacks activity against 'APE' organisms (Acinetobacter, Pseudomonas, Enterococcus).
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