The rate of Isoniazid metabolism varies significantly among individuals due to genetic polymorphisms in which enzyme?
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Correct answer: N-acetyltransferase
Isoniazid is cleared mainly by hepatic acetylation via N-acetyltransferase 2, an enzyme with well-known genetic polymorphisms. Slow acetylators reach higher plasma levels and face a greater risk of peripheral neuropathy, while fast acetylators clear the drug quickly.
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