Gastrointestinal Pathology · Pathology

Which of the following macroscopic features is most suggestive of Crohn disease rather than Ulcerative Colitis?

  1. Continuous involvement starting from the rectum
  2. Strictures and 'creeping fat' around the serosa
  3. Superficial mucosal ulcerations (pseudopolyps)
  4. Loss of haustral folds (lead pipe appearance)
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Correct answer: Strictures and 'creeping fat' around the serosa

Crohn disease is characterized by transmural inflammation, which leads to complications like strictures and fistulas. 'Creeping fat' occurs when mesenteric fat extends around the serosal surface of the bowel toward the anti-mesenteric border.

Difficulty: Medium Question 3 of 20

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