The 'Signet ring' cell type of gastric adenocarcinoma is primarily associated with which of the following?
Show answer and explanation
Correct answer: Diffuse growth pattern with linitis plastica
Diffuse gastric cancer (Lauren classification) is composed of discohesive cells that do not form glands. These cells often have large mucin vacuoles that push the nucleus to the periphery, creating a signet ring appearance and leading to a thickened, rigid stomach wall (linitis plastica).
Keep practicing
More Gastrointestinal Pathology questions
- Which of the following describes 'Hirschsprung disease'?
- A biopsy of the small intestine in a patient with Celiac disease would most likely show:
- Which microscopic finding is pathognomonic for pseudomembranous colitis caused by Clostridioides difficile?
- What is the most common site for a 'Peptic Ulcer' to occur?
- Which of the following polyps has the highest potential for malignant transformation into adenocarcinoma?
- Gardner syndrome is a clinical variant of Familial Adenomatous Polyposis (FAP) that includes which of the following extra-intestinal manife…