A 45-year-old male presents with chronic gastritis. A biopsy of the antrum reveals curved, rod-shaped organisms in the mucus layer. Which of the following is the most likely long-term complication if left untreated?
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Correct answer: Low-grade B-cell gastric MALT lymphoma
H. pylori infection causes chronic inflammation that can lead to lymphoid follicle formation. This chronic antigenic stimulation is the primary driver for the development of low-grade B-cell mucosal-associated lymphoid tissue (MALT) lymphoma.
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