Gastrointestinal Pathology · Pathology

Gardner syndrome is a clinical variant of Familial Adenomatous Polyposis (FAP) that includes which of the following extra-intestinal manifestations?

  1. CNS medulloblastoma and glial tumors
  2. Osteomas of the mandible and epidermal cysts
  3. Perioral and acral melanotic pigmented macules
  4. Hepatic hemangiomas and focal nodular lesions
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Correct answer: Osteomas of the mandible and epidermal cysts

Gardner syndrome is caused by APC gene mutations. It is characterized by the thousands of colonic polyps seen in FAP along with osteomas, epidermal cysts, and desmoid tumors.

Difficulty: Medium Question 10 of 20

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