Which of the following is an established biomarker found in the cerebrospinal fluid (CSF) of patients with Alzheimer disease?
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Correct answer: Low Aβ42 and high Tau
In AD, Aβ42 levels decrease in the CSF (as it is sequestered in brain plaques), while total Tau and phosphorylated Tau levels increase due to neuronal death and tangle formation.
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