Benign and Malignant Tumors · Pathology

Which of the following is a systemic effect most commonly associated with malignant tumors but rare in benign ones?

  1. Local compression of nerves
  2. Cachexia (wasting of fat and lean muscle mass)
  3. Obstruction of a hollow organ
  4. Autonomous ectopic secretion of otherwise-normal endocrine hormones
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Correct answer: Cachexia (wasting of fat and lean muscle mass)

Cachexia is a paraneoplastic syndrome characterized by profound weight loss and wasting, driven by cytokines like TNF-alpha and IL-6 produced by the tumor or the host immune response. Benign tumors generally do not cause cachexia unless they interfere with eating.

Difficulty: Medium Question 19 of 20

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