Benign and Malignant Tumors · Pathology

Which of the following is the most definitive criterion used to distinguish a malignant tumor from a benign tumor?

  1. Rapid rate of growth
  2. Presence of mitotic figures
  3. Evidence of metastasis
  4. Large tumor size
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Correct answer: Evidence of metastasis

Metastasis is the most reliable sign of malignancy, as benign tumors never metastasize. While rapid growth and mitosis can occur in both, only malignant cells have the ability to implant in non-contiguous sites.

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