Benign and Malignant Tumors · Pathology

A tumor is described as being 'well-differentiated.' What does this indicate about its biological behavior?

  1. It is likely a highly aggressive malignant tumor
  2. It closely resembles the normal cells of the tissue of origin
  3. It has completely lost the ability to perform its original function
  4. It is composed entirely of stem cells
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Correct answer: It closely resembles the normal cells of the tissue of origin

Differentiation refers to the extent to which neoplastic cells resemble their normal counterparts. Well-differentiated tumors (typical of most benign and low-grade malignant tumors) retain the architecture and function of the original tissue.

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