What is the primary target cell for the Epstein-Barr Virus (EBV) when causing Infectious Mononucleosis?
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Correct answer: B-lymphocytes via the CD21 receptor
EBV infects B-cells by binding to the CD21 (CR2) complement receptor. This infection leads to B-cell proliferation, which in turn triggers a massive response of atypical CD8+ T-cells seen in the peripheral blood.
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