In Type III hypersensitivity, what is the primary cause of neutrophilic recruitment to the site of immune complex deposition?
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Correct answer: C5a generated by complement activation
Complement activation by immune complexes generates C5a, which is a potent chemoattractant for neutrophils. Neutrophils then attempt to phagocytose the complexes but instead release lysosomal enzymes that damage the surrounding tissue.
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