What is the primary immunological defect in the development of Type 1 Diabetes Mellitus?
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Correct answer: T-cell mediated pancreatic beta cell destruction
Type 1 Diabetes is a T-cell mediated autoimmune disease. Islet-infiltrating lymphocytes (insulitis), specifically CD8+ cytotoxic T-cells, destroy the insulin-producing beta cells in the islets of Langerhans.
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