Which of the following laboratory findings helps distinguish Vitamin B12 deficiency from Folate deficiency?
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Correct answer: Elevated methylmalonic acid (MMA)
Both B12 and Folate deficiency cause elevated homocysteine. However, only B12 is required for the conversion of methylmalonyl-CoA to succinyl-CoA; therefore, MMA is elevated only in B12 deficiency.
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