What is the biochemical role of the 'folate trap' in Vitamin B12 deficiency?
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Correct answer: Folate is stuck in the N5-methyltetrahydrofolate form
Without Vitamin B12, folate cannot be converted from N5-methyltetrahydrofolate back into tetrahydrofolate. This 'traps' folate in a metabolically inactive form, effectively causing a functional folate deficiency even if folate levels are normal.
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