A patient with Vitamin B12 deficiency presents with 'Subacute Combined Degeneration' of the spinal cord. Which tracks are primarily involved?
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Correct answer: Dorsal columns and corticospinal tracts
B12 deficiency leads to the accumulation of methylmalonic acid, which is toxic to myelin. This causes demyelination of the posterior (dorsal) columns and the lateral corticospinal tracts, leading to loss of vibration sense and spasticity.
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