Which of the following drugs is a known dihydrofolate reductase inhibitor that can cause megaloblastic changes?
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Correct answer: Methotrexate
Methotrexate is a folate antagonist that inhibits dihydrofolate reductase, the enzyme responsible for regenerating active folate. This interference with the folate cycle inhibits DNA synthesis and can lead to megaloblastic anemia.
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More Megaloblastic Anemia questions
- The presence of 'Howell-Jolly bodies' in a megaloblastic patient typically indicates:
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