Which of the following best explains organ dysfunction in systemic amyloidosis?
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Correct answer: Amyloid deposits replacing normal parenchyma
In systemic amyloidosis, extracellular deposition of amyloid fibrils compresses and replaces normal tissue structures. This disruption impairs organ function without necessarily causing inflammation.
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More Amyloidosis questions
- Which of the following best describes the biochemical nature of amyloid deposits?
- Congo red staining of amyloid deposits under polarized light demonstrates which characteristic feature?
- AL amyloidosis is most commonly associated with which underlying condition?
- AA amyloidosis most frequently develops secondary to which of the following?
- In systemic amyloidosis, which organ is most commonly affected leading to nephrotic syndrome?
- Beta-amyloid deposits in the brain are characteristically associated with which condition?